ZINC SULFATE FOLIC ACID TABLETS / FOLINZ

     

COMPOSITION

Each sugar – coated tablet contains:

Zinc sulfate monohydrate USP - 55mg

Folic Acid                                BP – 5 mg

Colours ponceau 4R & titanium Dioxide BP

DESCRIPTION:

folinz is a single tablet containing Folic Acid and Zinc, which makes it an important vitamin nutritional supplement, Zinc is a vital trace element plying multiple role in the human body. Zinc boosts up immunity, improves resistance in disease conditions. Zinc also plays a major role in many metabolic activities in the body. Folic acid helps to prevent first occurrence of spina bifida and other neural tube defects in the newborn.

PHARMACOLOGY:

PHARMACOKINETICS:

Folic acid is absorbed mainly from the proximal part of the small intestine. Folate polyglutamates are considered to be de – conjugated to monoglutamates during absorption. Folic acid rapidly appears in the blood, where it is extensively bound to plasma proteins. The amounts of Folic acid absorbed from normal diets are rapidly distributed in body tissues and about 4 to 5 micrograms is excreted in the urine daily. When larger amounts are absorbed, a high proportion is metabolised in the liver to other active forms of folate and a proportion is stored as reduced and methylated folate. Larger amounts of folate are rapidly excreted in the urine. Zinc and its salts are poorly absorbed from  GIT (in duodenum and ileum) and only small portion of dietary Zinc is absorbed and is widely distributed throughout the body and excreted mainly in the feces and only traces are found in the urine since kidney has little role in regulating body Zinc content. Endogenous Zinc be reabsorbed in ileum and colon creating enterohepatic circulation of Zinc. After absorption Zinc is bound in the intestines to protein metallo thionein. Zinc is primarily stored in RBCs, WBCs, muscle, bone, Skin, Kidneys, Liver, pancreas,  retina, prostate etc, The extent of binding is 0%  to plasma albumin, 30-40%  to alpha 2 macroglobulins or transferrin and 1% to amino acids like histidine and cysteinc. Peak peas ma concentration occurs in approximately 2 hours and elimination is primarily fecal constituting 90%  and small amounts in urine and sweat.

PHARMACODYNAMICS:

 The daily folate requirement rises steeply during the final trimester of pregnancy, and evidence of maternal depletion may be found. To ensure normal tissue folate levels in the mother after delivery a daily supplement of about 300 micrograms is required during the second and third trimester of pregnancy. This does not obscure the blood picture of addisonian pernicious anaemia.

Zinc is an essential element of nutrition and traces are present is wide range of foods.

Zinc is an essential element of nutrition and traces are present is wide range of foods Zinc salts (usually Zinc sulfate) are used as supplements to correct Zinc deticiency and have been used to treat large number of conditions because of an associated reduction in the concentration of Zinc in the body

INDICATIONS:

folinz is recommended as a Vitamin & Zinc supplement and are in especially beneficial in following condition:

                     For the prophylaxis and treatment of nutritional megaloblastic anaemias associated with folic acid deficiency, as in the anaemias of pregnancy, pellagra, sprue and that following gastrectomy and in pernicious anaemia.

                   Vital role in various intercellular reactions likely conversion of Serine, glycine,  Synthesis of Purines, DNA and RNA.

                  Coenzyme  for metabolic processes.

                  Used in the treatment of folate deficiency.

                  Boosting up  Immunities.

                  Proper  growth of foetus.

                   For the periconceptual  supplementation of Folic Acid to help prevent first occurrence of spina bifida and other neural tube defects in the new born.

                 Prevent foetus malformations due to Zinc deficiency in pregnancy.

CONTRAINDICATIONS:

 folinz in contraindicated in patients with known hypersensitivity to any of the ingedients  in the formulation. It should never be used in the therapy of patients with vitamin B12 deficiency of any cause unless here is associated folate deficiency. Proper haematological diagnosis is essential.

WARNING:

Concurrent administration of Zinc might diminish the effect of penicillamine. Folic should never be given alone in the treatment of Addison’ s pernicous anaemia and other vitamin B 12 deficiency states because it may precipitate the onset of subacute combined degeneration of the spinal cord.

SIDE EFFECTS:

folinz is generally well tolerated in recommended doses. Rare side effects may include gastro – intestinal disturbances, nausea, vomiting and diarrhoea. Accumulation of Zinc may occur in cases of renal failure.

PREGNANCY AND LACTATION:

 there is published evidence that folic acid is beneficial in the prevention of neural tube defects.

INTERACTIONS:

folic acid occasionally reduces plasma levels of anticonvulsants. Particularly  phenytoin.

DOSAGE:

 As directed by the Physician.

OVERDOSAGE:

No cases of acute overdosage of Folic acid appear to have been reported, but even extremely hihg doses are unlikely to cause harm to patients.

PRESENTATION:

Folinz tablets are available in blister strip of 30 tablets in an attractive carton.

STORAGE:

 Store below 25 C in a dry a place. Protect from light Keep out of reach of children.